The always-great PyOhio 2016 has recently been announced, and will be held on July 30-31, 2016. PyOhio is:
A free annual conference for Python programmers in and around Ohio, the entire Midwest, maybe even the whole world.
The Call for Proposals <http://pyohio.org/call-for-proposals/> is currently up and open until May 15, so get your talk proposal in soon! PyOhio is great, for frist-time speakers, so if you've never spoken at a conference before, this is the place to start. Even if you've spoken at dozens of conferences, this is one you don't want to miss.
To keep up with what's happening with the conference, be sure to follow them on twitter at @pyohio.