PyOhio 2015 has recently been announced, and registration is now open! In their own words, PyOhio is:

A free annual conference for Python programmers in and around Ohio, the entire Midwest, maybe even the whole world.

Having attended for the past few years, I highly recommend this conference. You'll see high-quality talks, and meet great pythonistas from around the world (really!).

To keep up with what's happening with the conference, be sure to follow them on twitter at @pyohio.